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The complex relationship between them and human health extends beyond their traditional function in gut health and has attracted considerable interest due to their extensive potential in disease treatment (95)

This was demonstrated by the fact that administration of the peptide counteracted 5-HT receptor-dependent symptoms induced by pargyline + L-tryptophan, i.e., hyperthermia and wet dog shake related to 5-HT2A agonism, but not 5-HT1A-related forepaw treading, hind limb abduction, or hypothermia

Long term treatment with metformin significantly reduced transaminase concentrations and liver size.44 Thiazolidinediones have been shown to improve insulin sensitivity in patients with type 2 diabetes, they decrease serum aminotransferase levels, decrease liver fat, and improve the histological features of steatohepatitis (steatosis, ballooning necrosis, and centrilobular inflammation).45 The control of serum glucose and lipids levels should be part of the management

Elnahas et al

However, key structural differences are observed in the VP1 -barrel pocket, loop regions, and the N- and C-termini of the proteins